Article
Linkage analysis in keratoconus: replication of locus 5q21.2 and identification of other suggestive Loci.
Investigative ophthalmology & visual science - 1 Mar 2009
Bisceglia Luigi, De Bonis Patrizia, Pizzicoli Costantina, Fischetti Lucia, Laborante Antonio, Di Perna Michele, Giuliani Francesco, Delle Noci Nicola, Buzzonetti Luca, Zelante Leopoldo
Abstract excerpt
PURPOSE: Keratoconus (KC) is the most common indication for corneal transplantation in the Western world, with etiologic mechanisms still poorly understood. The disease prevalence in the general population is approximately 1:2000, and familial aggregation, together with increased familial risk, suggests important genetic influences on its pathogenesis. To date, several loci for familial keratoconus have been...
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