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Article

Loss of NKX3.1 Favors Vascular Endothelial Growth Factor-C Expression in Prostate Cancer

30 Oct 2008

Abstract excerpt

Decreased levels of the prostate-specific homeobox protein NKX3.1 are correlated with hormone-refractory and metastatic prostate cancer. Thus, it is compelling to define the NKX3.1-regulated genes that may be important for the progression of the advanced stage of the disease. In this study, we showed that vascular endothelial growth factor-C (VEGF-C) is one such target gene of NKX3.1. NKX3.1 inhibited VEGF-C...

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PMID: 18974119
DOI: 10.1158/0008-5472.can-08-1912

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