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Selective Degradation Permits a Feedback Loop Controlling Annexin A6 and Cholesterol Levels in Endolysosomes of NPC1 Mutant Cells.

Cells - 7 May 2020

Meneses-Salas Elsa, García-Melero Ana, Blanco-Muñoz Patricia, Jose Jaimy, Brenner Marie-Sophie, Lu Albert, Tebar Francesc, Grewal Thomas, Rentero Carles, Enrich Carlos

Abstract excerpt

We recently identified elevated annexin A6 (AnxA6) protein levels in Niemann-Pick-type C1 (NPC1) mutant cells. In these cells, AnxA6 depletion rescued the cholesterol accumulation associated with NPC1 deficiency. Here, we demonstrate that elevated AnxA6 protein levels in NPC1 mutants or upon pharmacological NPC1 inhibition, using U18666A, were not due to upregulated AnxA6 mRNA expression, but caused by defects in...

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PMID: 32392809
DOI: 10.3390/cells9051152
PMCID: PMC7291204

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