Article
Comparative analysis of the time-dependent functional and molecular changes in spinal cord degeneration induced by the G93A SOD1 gene mutation and by mechanical compression.
BMC genomics - 23 Oct 2008
Malaspina Andrea, Jokic Natasa, Huang Wenlong L, Priestley John V
Abstract excerpt
BACKGROUND: Mutations of the superoxide dismutase 1 (SOD1) gene are linked to amyotrophic lateral sclerosis (ALS), an invariably fatal neurological condition involving cortico-spinal degeneration. Mechanical injury can also determine spinal cord degeneration and act as a risk factor for the development of ALS. RESULTS: We have performed a comparative ontological analysis of the gene expression profiles of...
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