Article
Whole-genome analysis of diverse Chlamydia trachomatis strains identifies phylogenetic relationships masked by current clinical typing.
Nature genetics - 11 Mar 2012
Harris Simon R, Clarke Ian N, Seth-Smith Helena M B, Solomon Anthony W, Cutcliffe Lesley T, Marsh Peter, Skilton Rachel J, Holland Martin J, Mabey David, Peeling Rosanna W, Lewis David A, Spratt Brian G, Unemo Magnus, Persson Kenneth, Bjartling Carina, Brunham Robert, de Vries Henry J C, Morré Servaas A, Speksnijder Arjen, Bébéar Cécile M, Clerc Maïté, de Barbeyrac Bertille, Parkhill Julian, Thomson Nicholas R
Abstract excerpt
Chlamydia trachomatis is responsible for both trachoma and sexually transmitted infections, causing substantial morbidity and economic cost globally. Despite this, our knowledge of its population and evolutionary genetics is limited. Here we present a detailed phylogeny based on whole-genome sequencing of representative strains of C. trachomatis from both trachoma and lymphogranuloma venereum (LGV) biovars from...
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