The genetic basis of Parkinson's disease.

doi:10.1136/jnnp.73.4.363

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Article

The genetic basis of Parkinson's disease.

Journal of neurology, neurosurgery, and psychiatry - 1 Oct 2002

Foltynie T, Sawcer S, Brayne C, Barker R A

Abstract excerpt

Although the mechanisms underlying neurodegeneration in Parkinson's disease are not fully understood, considerable evidence suggests that genetic factors can influence susceptibility to the disease. In this article, we critically review this evidence and examine studies estimating patterns of inheritance. In a few families, Parkinson's disease is clearly inherited in a Mendelian fashion, and in some of these the...

Topics

Chromosome Aberrations
Chromosomes, Human, Pair 1
Chromosomes, Human, Pair 2
Chromosomes, Human, Pair 4
Chromosomes, Human, Pair 6
Cytochrome P-450 CYP2D6
Environment
Genetic Linkage
Genetic Predisposition to Disease
Humans
Ligases
Mitochondrial Diseases
Parkinson Disease
Polymorphism, Genetic
Twins
Ubiquitin-Protein Ligases

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Identifiers

PMID: 12235301
DOI: 10.1136/jnnp.73.4.363
PMCID: PMC1738059

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