Changes in phenotypically distinct mucosal macrophage populations may be a prerequisite for the development of inflammatory bowel disease.

doi:10.1111/j.1365-2249.1991.tb05757.x

Back to search

Article

Changes in phenotypically distinct mucosal macrophage populations may be a prerequisite for the development of inflammatory bowel disease.

Clinical and experimental immunology - 1 Sept 1991

Allison M C, Poulter L W

Abstract excerpt

Previous studies have demonstrated the presence of much more marked macrophage heterogeneity in colonic mucosa affected by the idiopathic inflammatory bowel diseases (ulcerative colitis and Crohn's disease) than in normal mucosa. This study examines the morphology, distribution and phenotypic expression of mucosal macrophage-like cells in biopsies from patients with idiopathic inflammatory bowel disease in...

Topics

Adolescent
Adult
Aged
Antibodies, Monoclonal
Fluorescent Antibody Technique
Humans
Immunoenzyme Techniques
Inflammatory Bowel Diseases
Intestinal Mucosa
Macrophages
Middle Aged

Phenotype

Pilot Projects

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 8 closest

Changes in phenotypically distinct mucosal macrophage populations may be a prerequisite for the development of inflammatory bowel disease.PMID 1893632Read

Phenotypic analysis of intestinal non-inflamed mucosa in Crohn's disease: evidence of mononuclear cell depletion in lamina propria.Semantic proximity Read

Intrinsic Gastrointestinal Macrophages: Their Phenotype and Role in Gastrointestinal MotilitySemantic proximity Read

Isolation and phenotypic characterization of colonic macrophages.Semantic proximity Read

Altered intestinal macrophage phenotype in ovine paratuberculosis.Semantic proximity Read

Macrophage polarization in inflammatory bowel disease.Semantic proximity Read

The role of the macrophage in sentinel responses in intestinal immunity.Semantic proximity Read

Macrophages in Ulcerative Colitis: Immunomodulatory Roles, Phenotypic Switching, and Therapeutic Targeting.Semantic proximity Read

Colonic macrophage polarization in homeostasis, inflammation, and cancer.Semantic proximity Read