Deficient synthesis of MTHFD, a trifunctional folate-dependent enzyme, in the CHO Ade E mutant.

doi:10.1007/BF01233064

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Article

Deficient synthesis of MTHFD, a trifunctional folate-dependent enzyme, in the CHO Ade E mutant.

Somatic cell and molecular genetics - 1 Jul 1991

Mascisch A, Rozen R

Abstract excerpt

MTHFD is a folate-dependent trifunctional protein comprised of three activities: N5,N10-methylenetetrahydrofolate dehydrogenase, N5,N10-methenyltetrahydrofolate cyclohydrolase, and N10-formyltetrahydrofolate synthetase. The enzymes catalyze sequential interconversion of tetrahydrofolate derivativ...

Topics

Amidophosphoribosyltransferase
Aminohydrolases
Animals
Blotting, Southern
Cell Line
Cricetinae
Cricetulus
Female
Folic Acid
Formate-Tetrahydrofolate Ligase
Methylenetetrahydrofolate Dehydrogenase (NADP)
Multienzyme Complexes
Mutation
Ovary
RNA Processing, Post-Transcriptional

Source

Open in PubMed

Identifiers

PMID: 1887335
DOI: 10.1007/BF01233064

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1887335-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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