Article
Genetic markers of IgG influence the outcome of infection with hepatitis C virus.
The Journal of infectious diseases - 1 Nov 2008
Pandey Janardan P, Namboodiri Aryan M, Luo Yuqun, Wu Yuping, Elston Robert C, Thomas David L, Rosen Hugo R, Goedert James J
Abstract excerpt
We examined the role that immunoglobulin GM and KM allotypes-genetic markers of gamma and kappa chains, respectively-play in the outcome of hepatitis C virus (HCV) infection in white Americans. A total of 119 persons who had cleared HCV and 111 with persistent HCV infection were genotyped for the presence of several GM and KM determinants. Persistent HCV infection was more than three times as likely (odds ratio,...
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