Article
Single base extension in multiplex blood group genotyping.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2009
Denomme Gregory A
Abstract excerpt
Transfusion recipients who become alloimmunized to blood group antigens require antigen-negative blood to limit adverse transfusion reactions. An alternative strategy to phenotyping blood is to assay genomic DNA for the associated single nucleotide polymorphisms (SNPs). A multiplex PCR coupled with a single base oligonucleotide extension assay using genomic DNA can identify SNPs related to D, C/c, E/e, S/s, K/k,...
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