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Abnormal DNA Methylation of <i>CD133</i> in Colorectal and Glioblastoma Tumors

30 Sept 2008

Abstract excerpt

Much recent effort has focused on identifying and characterizing cellular markers that distinguish tumor propagating cells (TPC) from more differentiated progeny. We report here an unusual promoter DNA methylation pattern for one such marker, the cell surface antigen CD133 (Prominin 1). This protein has been extensively used to enrich putative cancer propagating stem-like cell populations in epithelial tumors...

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PMID: 18829568
DOI: 10.1158/0008-5472.can-07-6208

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