Article
The impact of sodium chloride and volume depletion in the chronic kidney disease of congenital chloride diarrhea.
Kidney international - 1 Oct 2008
Wedenoja Satu, Ormälä Timo, Berg Ulla B, Halling Stella F Edström, Jalanko Hannu, Karikoski Riitta, Kere Juha, Holmberg Christer, Höglund Pia
Abstract excerpt
Congenital chloride diarrhea is due to mutations in the intestinal Cl(-)/HCO(3)(-) exchange (SLC26A3) which results in sodium chloride and fluid depletion leading to hypochloremic and hypokalemic metabolic alkalosis. Although treatment with sodium and potassium chloride offers protection from renal involvement in childhood, the long-term renal outcome remains unclear. Here we describe two cases of congenital...
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