Article
Natural selection fails to optimize mutation rates for long-term adaptation on rugged fitness landscapes.
PLoS computational biology - 26 Sept 2008
Clune Jeff, Misevic Dusan, Ofria Charles, Lenski Richard E, Elena Santiago F, Sanjuán Rafael
Abstract excerpt
The rate of mutation is central to evolution. Mutations are required for adaptation, yet most mutations with phenotypic effects are deleterious. As a consequence, the mutation rate that maximizes adaptation will be some intermediate value. Here, we used digital organisms to investigate the ability of natural selection to adjust and optimize mutation rates. We assessed the optimal mutation rate by empirically...
Topics
- Adaptation, Physiological
- Biological Evolution
- Computational Biology
- Computer Simulation
- Models, Genetic
- Mutation
- Selection, Genetic
- Time Factors