Article
Increased mutation rate in bacteria overexpressing a cloned foreign gene.
Mutation research - 1 Sept 1991
Lukacsovich T, Venetianer P
Abstract excerpt
Escherichia coli cells growing slowly as a result of the overexpression of a cloned foreign gene were shown to exhibit an increased mutation rate in the foreign gene as well as in several non-selected markers. This phenomenon is discussed in terms of the model proposed by Hall (1990).
Topics
- Chromosomes, Bacterial
- Cloning, Molecular
- Escherichia coli
- Genes, Bacterial
- Lac Operon
- Mutation
- Plasmids
- Transformation, Bacterial