Article
Clinical significance of pretreatment serum amphiregulin and transforming growth factor-alpha, and an epidermal growth factor receptor somatic mutation in patients with advanced non-squamous, non-small cell lung cancer.
Cancer science - 1 Nov 2008
Masago Katsuhiro, Fujita Shiro, Hatachi Yukimasa, Fukuhara Akiko, Sakuma Keiichiro, Ichikawa Masataka, Kim Yung Haku, Mio Tadashi, Mishima Michiaki
Abstract excerpt
Circulating amphiregulin and transforming growth factor-alpha (TGF-alpha) have been found to be correlated with an unfavorable response to gefitinib based on the identification of patients with a higher probability of resistance to the drug. However, the association between an epidermal growth factor receptor (EGFR) somatic mutation and the overexpression of its ligands has not been determined. To verify the...
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