Article
Genetic and environmental determinants on bone loss in postmenopausal Caucasian women: a 14-year longitudinal twin study.
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA - 1 Jun 2009
Zhai G, Andrew T, Kato B S, Blake G M, Spector T D
Abstract excerpt
SUMMARY: This longitudinal twin study documented that genetic factors explain 44-56% of the between-individual variance in bone loss at femoral neck, lumbar spine, and forearm in postmenopausal Caucasian women, providing a rationale for identifying the specific genes involved. INTRODUCTION: Although there is a significant genetic effect on peak BMD, until recently, no substantive studies on heritability of bone...
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