Article
Copy number variations and risk for schizophrenia in 22q11.2 deletion syndrome.
Human molecular genetics - 15 Dec 2008
Bassett Anne S, Marshall Christian R, Lionel Anath C, Chow Eva W C, Scherer Stephen W
Abstract excerpt
22q11.2 Deletion Syndrome (22q11.2DS) is a common microdeletion syndrome with congenital and late-onset features. Testing for the genomic content of copy number variations (CNVs) may help elucidate the 22q11.2 deletion mechanism and the variable clinical expression of the syndrome including the high (25%) risk for schizophrenia. We used genome-wide microarrays to assess CNV content and the parental origin of...
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