Article
Plasmodium vivax circumsporozoite variants and Duffy blood group genotypes in the Brazilian Amazon region.
Transactions of the Royal Society of Tropical Medicine and Hygiene - 1 Jul 2009
Storti-Melo Luciane M, de Souza-Neiras Wanessa C, Cassiano Gustavo C, Joazeiro Ana C P, Fontes Cor J, Bonini-Domingos Cláudia R, Couto Alvaro A R D'Almeida, Povoa Marinete M, de Mattos Luiz C, Cavasini Carlos E, Rossit Andréa R B, Machado Ricardo L D
Abstract excerpt
The circumsporozoite protein (CSP) of the Plasmodium vivax infective sporozoite is considered to be a major target for the development of recombinant malaria vaccines. The Duffy blood group molecule acts as the red blood cell receptor for P. vivax. We review the frequency of P. vivax CSP variants...
Topics
- Animals
- Brazil
- Duffy Blood-Group System
- Female
- Genetic Variation
- Genotype
- Humans
- Malaria, Vivax
- Male
- Plasmodium vivax
- Polymerase Chain Reaction
