[In vitro generation of mutants of Klebsiella pneumoniae following exposure to fluorquinolones. Relationship with the presence of extended spectrum betalactamases].

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[In vitro generation of mutants of Klebsiella pneumoniae following exposure to fluorquinolones. Relationship with the presence of extended spectrum betalactamases].

Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia - 1 Sept 2008

Noguera O, Rodríguez J C, Cremades R, Ruiz M, Royo G

Abstract excerpt

In order to provide data that may help to explain the relationship between production of extended spectrum betalactamases and fluorquinolone resistance in Klebsiella pneumoniae, we have developed an in vitro model of exposure to sub-inhibitory concentrations of various fluorquinolones (ciprofloxacin, levofloxacin and moxifloxacin) in two strains, one of which is a producer of extended spectrum betalactamases...

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[In vitro generation of mutants of Klebsiella pneumoniae following exposure to fluorquinolones. Relationship with the presence of extended spectrum betalactamases].

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