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Article

Adenovirus-based targeting in myoblasts is hampered by nonhomologous vector integration.

Human gene therapy - 1 Oct 2008

Isman Olga, Roberts Michael L, Morgan Jennifer E, Graham Ian R, Goldring Kirstin, Lawrence-Watt Diana J, Lu Qi Long, Dunckley Matthew G, Porter Andrew C G, Partridge Terence A, Dickson George

Abstract excerpt

Chromosomal correction of dystrophin gene mutations is a most desirable therapeutic solution for Duchenne muscular dystrophy, as it allows production of the full-length dystrophin under the control of locus-specific promoters. Here we explored gene targeting in conditionally immortal mouse dystrophin-deficient myoblasts. We constructed an adenoviral vector for the correction of the mdx mutation, containing 6.0 kb...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Dystrophin

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Share to Muscular Dystrophy, Duchenne

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Source

Identifiers

PMID: 18788904
DOI: 10.1089/hum.2008.063

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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