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Article

Relevance of the amino acid conversions L144R (Zaragoza) and L159P (Zavalla) in the apolipoprotein A-I binding site for haptoglobin.

Biological chemistry - 1 Nov 2008

Cigliano Luisa, D'Andrea Luca D, Maresca Bernardetta, Serino Milena, Carlucci Alessandro, Salvatore Alfonso, Spagnuolo Maria Stefania, Scigliuolo Graziana, Pedone Carlo, Abrescia Paolo

Abstract excerpt

The high-density lipoprotein apolipoprotein A-I (ApoA-I) stimulates the enzyme lecithin-cholesterol acyltransferase (LCAT) in the reverse cholesterol transport pathway. Two ApoA-I variants, Zaragoza (L144R) and Zavalla (L159P), are associated with low levels of HDL-cholesterol but normal LCAT activity. Haptoglobin interacts with ApoA-I, impairing LCAT stimulation. Synthetic peptides matching the...

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Share to Apolipoprotein A-I
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18783334
DOI: 10.1515/BC.2008.156

Genes

LCAT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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