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Article

Dosage compensation by gene-copy silencing in a triploid hybrid fish.

Current biology : CB - 9 Sept 2008

Pala Irene, Coelho Maria M, Schartl Manfred

Abstract excerpt

In mammals, the increase in gene dosage, in the form of polyploidy or involving chromosomal fragments, has deleterious effects [1]. Regulation of appropriate gene product amounts has to be warranted by complex dosage-compensation mechanisms. Lower vertebrates, on the other hand, cope very well with ploidy increase [2-4], implying either effective compensation or a lack of necessity for such mechanisms....

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Identifiers

PMID: 18771921
DOI: 10.1016/j.cub.2008.07.096

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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