Article
Computational analysis of constraints on noncoding regions, coding regions and gene expression in relation to Plasmodium phenotypic diversity.
PloS one - 1 Sept 2008
Essien Kobby, Hannenhalli Sridhar, Stoeckert Christian J
Abstract excerpt
BACKGROUND: Malaria-causing Plasmodium species exhibit marked differences including host choice and preference for invading particular cell types. The genetic bases of phenotypic differences between parasites can be understood, in part, by investigating constraints on gene expression and genic sequences, both coding and regulatory. METHODOLOGY/PRINCIPAL FINDINGS: We investigated the evolutionary constraints on...
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