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Article

TaqMan-MGB probe quantitative PCR assays to genotype and quantify three mtDNA mutations of Leber hereditary optic neuropathy.

Scientific reports - 23 Jul 2020

Xue Bingqian, Li Yang, Wang Xin, Li Rui, Zeng Xin, Yang Meihua, Xu Xiaohui, Ye Tingbo, Bao Liming, Huang Yi

Abstract excerpt

Leber hereditary optic neuropathy (LHON) is a degenerative disease of the optic nerve associated with one of three mitochondrial DNA (mtDNA) m.3460G>A, m.11778G>A and m.14484T>C mutations. Although several procedures are available to genotype these mutations, quantitative approaches with rapid, low-cost and easy to handle advantages for three LHON mtDNA mutations are rarely reported. Here, we firstly developed a...

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Source

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Identifiers

PMID: 32704028
DOI: 10.1038/s41598-020-69220-7
PMCID: PMC7378831

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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