Article
Emerging Flt3 kinase inhibitors in the treatment of leukaemia.
Expert opinion on emerging drugs - 1 Mar 2006
Tickenbrock Lara, Müller-Tidow Carsten, Berdel Wolfgang E, Serve Hubert
Abstract excerpt
Acute myeloid leukaemia (AML) is characterised by the infiltration of the bone marrow with highly proliferative leukaemic cells that stop to differentiate at different stages of myeloid development and carry survival advantages. Conventionally, AML is treated with aggressive cytotoxic therapy, in eligible patients followed by allogeneic bone marrow transplantation. However, despite this aggressive treatment, many...
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