Article
Optimization of human plasma 1H NMR spectroscopic data processing for high-throughput metabolic phenotyping studies and detection of insulin resistance related to type 2 diabetes.
Analytical chemistry - 1 Oct 2008
Maher Anthony D, Crockford Derek, Toft Henrik, Malmodin Daniel, Faber Johan H, McCarthy Mark I, Barrett Amy, Allen Maxine, Walker Mark, Holmes Elaine, Lindon John C, Nicholson Jeremy K
Abstract excerpt
Optimizing NMR experimental parameters for high-throughput metabolic phenotyping requires careful examination of the total biochemical information obtainable from (1)H NMR data, which includes concentration and molecular dynamics information. Here we have applied two different types of mathematical transformation (calculation of the first derivative of the NMR spectrum and Gaussian shaping of the free-induction...
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