Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic basis of evolutionary adaptation by Escherichia coli to stressful cycles of freezing, thawing and growth.

Genetics - 1 Sept 2008

Sleight Sean C, Orlic Christian, Schneider Dominique, Lenski Richard E

Abstract excerpt

Microbial evolution experiments offer a powerful approach for coupling changes in complex phenotypes, including fitness and its components, with specific mutations. Here we investigate mutations substituted in 15 lines of Escherichia coli that evolved for 1000 generations under freeze-thaw-growth (FTG) conditions. To investigate the genetic basis of their improvements, we screened many of the lines for mutations...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adaptation, Physiological
Share to Cell Membrane

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Escherichia coli Proteins

Share to Evolution, Molecular

Share to Freezing

Share to Genes, Bacterial

Share to Nucleic Acid Hybridization

Share to Transcription, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 18757947
DOI: 10.1534/genetics.108.091330
PMCID: PMC2535694

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic basis of evolutionary adaptation by Escherichia coli to stressful cycles of freezing, thawing and growth.PMID 18757947Read ↗

Evolutionary adaptation to freeze-thaw-growth cycles in Escherichia coli.Semantic proximity Read ↗

Prokaryotic life finds a way: insights from evolutionary experimentation in bacteria.Semantic proximity Read ↗

Adaptive laboratory evolution of <i>Escherichia coli</i> under acid stressSemantic proximity Read ↗

Revisiting the Design of the Long-Term Evolution Experiment with Escherichia coli.Semantic proximity Read ↗

Insertion-sequence-mediated mutations both promote and constrain evolvability during a long-term experiment with bacteria.Semantic proximity Read ↗

Comparative genomics hints at dispensability of multiple essential genes in two Escherichia coli L-form strains.Semantic proximity Read ↗

Comparative genome sequencing of Escherichia coli allows observation of bacterial evolution on a laboratory timescale.Semantic proximity Read ↗

Evolution of Escherichia coli to 42 °C and subsequent genetic engineering reveals adaptive mechanisms and novel mutations.Semantic proximity Read ↗

The road not taken: Could stress-specific mutations lead to different evolutionary paths?Semantic proximity Read ↗

Insertion sequence-driven evolution of Escherichia coli in chemostats.Semantic proximity Read ↗

Evolutionary potential, cross-stress behavior and the genetic basis of acquired stress resistance in Escherichia coli.Semantic proximity Read ↗

Conditionally essential genes for survival during starvation in <i>Enterococcus faecium</i> E745Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.