Article
Definition of subtypes of essential thrombocythaemia and relation to polycythaemia vera based on JAK2 V617F mutation status: a prospective study.
Lancet (London, England) - 3 Dec 2005
Campbell Peter J, Scott Linda M, Buck Georgina, Wheatley Keith, East Clare L, Marsden Joanne T, Duffy Audrey, Boyd Elaine M, Bench Anthony J, Scott Mike A, Vassiliou George S, Milligan Donald W, Smith Steve R, Erber Wendy N, Bareford David, Wilkins Bridget S, Reilly John T, Harrison Claire N, Green Anthony R
Abstract excerpt
BACKGROUND: An acquired V617F mutation in JAK2 occurs in most patients with polycythaemia vera, but is seen in only half those with essential thrombocythaemia and idiopathic myelofibrosis. We aimed to assess whether patients with the mutation are biologically distinct from those without, and why the same mutation is associated with different disease phenotypes. METHODS: Two sensitive PCR-based methods were used...
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