Article
A weighted-Holm procedure accounting for allele frequencies in genomewide association studies.
Genetics - 1 Sept 2008
Dalmasso Cyril, Génin Emmanuelle, Trégouet David-Alexandre
Abstract excerpt
In the context of genomewide association studies where hundreds of thousand of polymorphisms are tested, stringent thresholds on the raw association test P-values are generally used to limit false-positive results. Instead of using thresholds based on raw P-values as in Bonferroni and sequential Sidak (SidakSD) corrections, we propose here to use a weighted-Holm procedure with weights depending on allele...
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