Article
When sporadic disease is not sporadic: the potential for genetic etiology.
Archives of neurology - 1 Feb 2004
Goldman Jill S, Miller Bruce L, Safar Jiri, de Tourreil Sunita, Martindale Jennifer L, Prusiner Stanley B, Geschwind Michael D
Abstract excerpt
BACKGROUND: Approximately 2% of Alzheimer disease cases and 10% to 15% of prion disease cases are due to mutations in autosomal dominant genes. Mutations have been found in patients without family histories of neurological disease. OBJECTIVES: To emphasize the need for consideration of a genetic etiology of prion disease and early-onset Alzheimer disease, regardless of the absence of a significant family history,...
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