Elevated frequency of p53 genetic mutations and AgNOR values in squamous cell carcinoma.

Abstract excerpt

BACKGROUND: Epidermal squamous cell carcinoma (SCC) isa common malignancy in Pakistan. We hypothesize that it is characterized by higher frequency of p53 genetic mutations and increased AgNOR values compared with squamous cell papilloma(SCP) and basal cell carcinoma (BCC). EXPERIMENTAL DESIGN: To test our hypothesis, 140 skin biopsies(including 20 normal skin, 20 SCP, 20 BCC and 80 SCC samples of various grades)...

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