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Article

Mutation associated with an autosomal dominant cone-rod dystrophy CORD7 modifies RIM1-mediated modulation of voltage-dependent Ca2+ channels.

Channels (Austin, Tex.) - 1 Jan 2000

Miki Takafumi, Kiyonaka Shigeki, Uriu Yoshitsugu, De Waard Michel, Wakamori Minoru, Beedle Aaron M, Campbell Kevin P, Mori Yasuo

Abstract excerpt

Genetic analyses have revealed an association between the gene encoding the Rab3A-interacting molecule (RIM1) and the autosomal dominant cone-rod dystrophy CORD7. However, the pathogenesis of CORD7 remains unclear. We recently revealed that RIM1 regulates voltage-dependent Ca(2+) channel (VDCC) currents and anchors neurotransmitter-containing vesicles to VDCCs, thereby controlling neurotransmitter release. We...

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Identifiers

PMID: 18690027
DOI: 10.4161/chan.4660
PMCID: PMC4850211

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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