Article
The molecular and functional phenotype of glomerular podocytes reveals key features of contractile smooth muscle cells.
American journal of physiology. Renal physiology - 1 Oct 2008
Saleem Moin A, Zavadil Jiri, Bailly Maryse, McGee Karen, Witherden Ian R, Pavenstadt Hermann, Hsu Hsianghao, Sanday Julia, Satchell Simon C, Lennon Rachel, Ni Lan, Bottinger Erwin P, Mundel Peter, Mathieson Peter W
Abstract excerpt
The glomerular podocyte is a highly specialized cell, with the ability to ultrafilter blood and support glomerular capillary pressures. However, little is known about either the genetic programs leading to this functionality or the final phenotype. We approached this question utilizing a human conditionally immortalized cell line, which differentiates from a proliferating epithelial phenotype to a differentiated...
Topics
- Actin Cytoskeleton
- Angiotensin II
- Cell Differentiation
- Cell Line, Transformed
- Cell Shape
- Epithelial Cells
- Gene Expression Profiling
- Humans
- Mesoderm