Article
A high-density association screen of 155 ion transport genes for involvement with common migraine.
Human molecular genetics - 1 Nov 2008
Nyholt Dale R, LaForge K Steven, Kallela Mikko, Alakurtti Kirsi, Anttila Verneri, Färkkilä Markus, Hämaläinen Eija, Kaprio Jaakko, Kaunisto Mari A, Heath Andrew C, Montgomery Grant W, Göbel Hartmut, Todt Unda, Ferrari Michel D, Launer Lenore J, Frants Rune R, Terwindt Gisela M, de Vries Boukje, Verschuren W M Monique, Brand Jan, Freilinger Tobias, Pfaffenrath Volker, Straube Andreas, Ballinger Dennis G, Zhan Yiping, Daly Mark J, Cox David R, Dichgans Martin, van den Maagdenberg Arn M J M, Kubisch Christian, Martin Nicholas G, Wessman Maija, Peltonen Leena, Palotie Aarno
Abstract excerpt
The clinical overlap between monogenic Familial Hemiplegic Migraine (FHM) and common migraine subtypes, and the fact that all three FHM genes are involved in the transport of ions, suggest that ion transport genes may underlie susceptibility to common forms of migraine. To test this leading hypothesis, we examined common variation in 155 ion transport genes using 5257 single nucleotide polymorphisms (SNPs) in a...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.