Article
3'-phosphoinositides regulate the coordination of speed and accuracy during chemotaxis.
Biophysical journal - 1 Oct 2008
Gruver J S, Wikswo J P, Chung C Y
Abstract excerpt
The PI3K/PTEN pathway, as the regulator of 3'-phosphoinositide (3'-PI) dynamics, has emerged as a key regulator of chemoattractant gradient sensing during chemotaxis in Dictyostelium and other cell types. Previous results have shown 3'-PIs to be important for regulating basal cell motility and sensing the direction and strength of the chemoattractant gradient. We examined the chemotaxis of wild-type cells and...
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