Article
A search for cyclophilin-A gene variants in cyclosporine A-treated renal transplanted patients.
Clinical transplantation - 1 Jan 2000
Moscoso-Solorzano Grace Tamara, Ortega Francisco, Rodríguez Isabel, García-Castro Mónica, Gómez Ernesto, Díaz-Corte Carmen, Baltar José M, Alvarez Victoria, Ortiz Alberto, Coto Eliecer
Abstract excerpt
BACKGROUND: The cyclophilin A (CypA)-cyclosporine (CsA) complex promotes immune response. The variation at the CypA gene could explain CsA-pharmacokinetics and clinical outcomes among CsA-treated patients. METHODS: The study included 290 kidney transplanted patients (65% male; mean age 51 +/- 15 yr), treated with CsA. The five CypA- exons and the promoter region were analysed through single-strand conformation...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.