Article
[Relationship between the secondary structure and the regulatory activity of the leader region of the riboflavin biosynthesis operon in Bacillus subtilis].
Genetika - 1 Apr 2008
Mironov A S, Karelov D V, Solov'eva I M, Eremina S Iu, Errais-Lopes L, Kreneva R A, Perumov D A
Abstract excerpt
Insertion and deletion mutagenesis of the leader region of the Bacillus subtilis rib operon encoding FMN-specific sensor RNA was conducted. Insertions of different structure and length in the conservative motif of the leader sequence (Rfn-element) were shown to cause partially constitutive expression of the operon resulted in an increased accumulation of riboflavin. At the same time, introducing into the genome...
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