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Article

Embryonic origin and Hox status determine progenitor cell fate during adult bone regeneration

24 Jul 2008

Abstract excerpt

The fetal skeleton arises from neural crest and from mesoderm. Here, we provide evidence that each lineage contributes a unique stem cell population to the regeneration of injured adult bones. Using Wnt1Cre::Z/EG mice we found that the neural crest-derived mandible heals with neural crest-derived skeletal stem cells, whereas the mesoderm-derived tibia heals with mesoderm-derived stem cells. We tested whether...

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PMID: 18653558
DOI: 10.1242/dev.023788

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