Article
Activity of the small modified amino acid alpha-hydroxy glycineamide on in vitro and in vivo human immunodeficiency virus type 1 capsid assembly and infectivity.
Antimicrobial agents and chemotherapy - 1 Oct 2008
Abdurahman Samir, Végvári Akos, Youssefi Masoud, Levi Michael, Höglund Stefan, Andersson Elin, Horal Peter, Svennerholm Bo, Balzarini Jan, Vahlne Anders
Abstract excerpt
Upon maturation of the human immunodeficiency virus type 1 (HIV-1) virion, proteolytic cleavage of the Gag precursor protein by the viral protease is followed by morphological changes of the capsid protein p24, which will ultimately transform the virus core from an immature spherical to a mature conical structure. Virion infectivity is critically dependent on the optimal semistability of the capsid cone...
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