Article
Overexpression of uvomorulin in a compaction-negative F9 mutant cell line.
Developmental biology - 1 Aug 1991
Calogero A, Samuels M, Darland T, Edwards S A, Kemler R, Adamson E D
Abstract excerpt
The mutant F9 cell line F9att-5.51 synthesizes reduced amounts of uvomorulin (UM) protein and we hypothesized earlier (Adamson, Baribault, and Kemler, Dev. Biol. (1990), 138, 338) that this may account for its inability to compact into tightly aggregated balls of cells. Subsequently, when 5.51 cells are treated with retinoic acid to stimulate their differentiation, they are unable to form embryoid bodies as do...
Topics
- Animals
- Base Sequence
- Cadherins
- Cell Line
- Endoderm
- Gene Expression Regulation, Neoplastic
- Mice
- Molecular Sequence Data
- Mutation
- Neoplastic Stem Cells
- Peptide Mapping