LRRK2 and Parkin mutations in a family with parkinsonism-Lack of genotype-phenotype correlation.

Abstract excerpt

Here we report the relationship between age at onset, clinical course and genotype in a family with combined LRRK2 G2019S and Parkin exon 2 deletions. In the combined mutation carriers the age at onset and clinical course was highly variable and not always younger than in the carriers of LRRK2 G2019S mutations alone.

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