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Article

Induction of apoptosis by phenethyl isothiocyanate in cells overexpressing Bcl-XL.

Cancer letters - 28 Nov 2008

Cuddihy Sarah L, Brown Kristin K, Thomson Susan J, Hampton Mark B

Abstract excerpt

Isothiocyanates are a class of phytochemicals able to induce apoptosis in numerous cells including Jurkat T-lymphoma cells overexpressing the oncoprotein Bcl-2. To test if isothiocyanates are also effective against other anti-apoptotic members of the Bcl-2 family we generated Jurkat cells stably overexpressing Bcl-X(L). Phenethyl isothiocyanate (PEITC) was cytotoxic to these cells, with an LD(50) ranging from 9...

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PMID: 18639976
DOI: 10.1016/j.canlet.2008.06.002

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