Gene deletions in Japanese patients with Duchenne and Becker muscular dystrophies: deletion study and carrier detection.

doi:10.1111/j.1399-0004.1991.tb03052.x

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Article

Gene deletions in Japanese patients with Duchenne and Becker muscular dystrophies: deletion study and carrier detection.

Clinical genetics - 1 Jun 1991

Asano J, Tomatsu S, Sukegawa K, Ikedo Y, Minami R, Iida M, Nishimura M, Nakagawa M, Ohshiro M, Orii T

Abstract excerpt

Fifty unrelated Japanese patients with Duchenne and Becker muscular dystrophy (DMD and BMD) have been studied through use of the dystrophin cDNA probes. The 14-kb dystrophin cDNA was subdivided into six subclones, and Hind III-digested DNAs were analyzed by Southern blotting. Of 50 unrelated patients, 20 showed a deletion of one or several of the exon-containing Hind III fragments (40.0%). These corresponded to...

Topics

Adolescent
Adult
Blotting, Southern
Child
Chromosome Deletion
Chromosome Mapping
DNA Probes
Deoxyribonuclease HindIII
Dosage Compensation, Genetic
Dystrophin
Female

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genetic Carrier Screening

Humans

Japan

Male

Muscular Dystrophies

Pedigree

Phenotype

Source

Open in PubMed

Identifiers

PMID: 1863988
DOI: 10.1111/j.1399-0004.1991.tb03052.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1863988-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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