Article
A limited association of generalized osteoarthritis with alleles at the type II collagen locus: COL2A1.
British journal of rheumatology - 1 Aug 1991
Priestley L, Fergusson C, Ogilvie D, Wordsworth P, Smith R, Pattrick M, Doherty M, Sykes B
Abstract excerpt
A significant genetic influence in osteoarthritis has been observed in the combination of Heberden's nodes and generalized osteoarthritis. We examined whether mutation in the gene encoding the major cartilage matrix protein type II collagen was responsible by comparing allele frequencies at the locus (COL2A1) in a group of 61 patients with nodal GOA with a control population and by analysing the COL2A1 genotypes...
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