Article
Sibling pair analysis shows no linkage of generalized osteoarthritis to the loci encoding type II collagen, cartilage link protein or cartilage matrix protein.
British journal of rheumatology - 1 Dec 1994
Loughlin J, Irven C, Fergusson C, Sykes B
Abstract excerpt
Generalized OA (GOA) is a well-characterized subset of primary OA which is strongly associated with the occurrence of Heberden's nodes. Using gene-specific highly polymorphic markers and affected sib pair (ASP) analyses, we have investigated genetic linkage between GOA and three cartilage matrix...
Topics
- Alleles
- Cartilage Oligomeric Matrix Protein
- Collagen
- Diseases in Twins
- Extracellular Matrix Proteins
- Family Health
- Genetic Linkage
- Genetic Markers
- Genetic Predisposition to Disease
- Genotype
- Glycoproteins
- Humans
- Matrilin Proteins
- Osteoarthritis
- Polymorphism, Genetic
- Proteins
- Proteoglycans