G/T substitution in intron 1 of the UNC13B gene is associated with increased risk of nephropathy in patients with type 1 diabetes.

doi:10.2337/db08-0073

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Article

G/T substitution in intron 1 of the UNC13B gene is associated with increased risk of nephropathy in patients with type 1 diabetes.

Diabetes - 1 Oct 2008

Trégouet David-Alexandre, Groop Per-Henrik, McGinn Steven, Forsblom Carol, Hadjadj Samy, Marre Michel, Parving Hans-Henrik, Tarnow Lise, Telgmann Ralph, Godefroy Tiphaine, Nicaud Viviane, Rousseau Rachel, Parkkonen Maikki, Hoverfält Anna, Gut Ivo, Heath Simon, Matsuda Fumihiko, Cox Roger, Kazeem Gbenga, Farrall Martin, Gauguier Dominique, Brand-Herrmann Stefan-Martin, Cambien François, Lathrop Mark, Vionnet Nathalie

Abstract excerpt

OBJECTIVE: Genetic and environmental factors modulate the susceptibility to diabetic nephropathy, as initiating and/or progression factors. The objective of the European Rational Approach for the Genetics of Diabetic Complications (EURAGEDIC) study is to identify nephropathy susceptibility genes. We report molecular genetic studies for 127 candidate genes for nephropathy. RESEARCH DESIGN AND METHODS:...

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PMID: 18633107
DOI: 10.2337/db08-0073
PMCID: PMC2551697

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