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Article

Coupling of mutated Met variants to DNA repair via Abl and Rad51.

Cancer research - 15 Jul 2008

Ganapathipillai Suganthini S, Medová Michaela, Aebersold Daniel M, Manley Paul W, Berthou Sylvie, Streit Bruno, Blank-Liss Wieslawa, Greiner Richard H, Rothen-Rutishauser Barbara, Zimmer Yitzhak

Abstract excerpt

Abnormal activation of DNA repair pathways by deregulated signaling of receptor tyrosine kinase systems is a compelling likelihood with significant implications in both cancer biology and treatment. Here, we show that due to a potential substrate switch, mutated variants of the receptor for hepatocyte growth factor Met, but not the wild-type form of the receptor, directly couple to the Abl tyrosine kinase and the...

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Identifiers

PMID: 18632630
DOI: 10.1158/0008-5472.CAN-08-1269

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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