Article
Virus-like particles of SARS-like coronavirus formed by membrane proteins from different origins demonstrate stimulating activity in human dendritic cells.
PloS one - 16 Jul 2008
Bai Bingke, Hu Qinxue, Hu Hui, Zhou Peng, Shi Zhengli, Meng Jin, Lu Baojing, Huang Yi, Mao Panyong, Wang Hanzhong
Abstract excerpt
The pathogenesis of SARS coronavirus (CoV) remains poorly understood. In the current study, two recombinant baculovirus were generated to express the spike (S) protein of SARS-like coronavirus (SL-CoV) isolated from bats (vAcBS) and the envelope (E) and membrane (M) proteins of SARS-CoV, respectively. Co-infection of insect cells with these two recombinant baculoviruses led to self-assembly of virus-like...
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