Article
An Escherichia coli asr mutant has decreased fitness during colonization in a mouse model.
Research in microbiology - 1 Jan 2000
Armalyte Julija, Seputiene Vaida, Melefors Ojar, Suziedeliene Edita
Abstract excerpt
The Escherichia coli asr gene, like its homologues in other enterobacteria, is strongly induced by low external pH. The E. coli asr mutant shows weakened ability to adapt to acidic pH. This suggests that the asr gene product is important for enterobacterial species, both commensal and pathogenic, in overcoming acid stress in the stomach and subsequently colonizing the intestine. We examined the relative fitness...
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