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Article

Tumorigenesis and neurodegeneration: two sides of the same coin?

BioEssays : news and reviews in molecular, cellular and developmental biology - 1 Aug 2008

Staropoli John F

Abstract excerpt

Dysregulation of genes that control cell-cycle progression and DNA repair is a hallmark of tumorigenesis. It is becoming increasingly apparent, however, that these defects also contribute to degeneration of post-mitotic neurons under certain conditions. The gene for ataxia-telangiectasia mutated (ATM) is a prototype for this dual mechanism of action, with loss-of-function mutations causing not only selective...

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Identifiers

PMID: 18623069
DOI: 10.1002/bies.20784

Genes

ATM

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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